A Reboot of the Immune System - Another Benefit of Fasting! (And Why the List Just Keeps Growing)
- Zachary Laboube
- Oct 21
- 4 min read
Updated: Nov 16
You’ve heard how fasting supports weight loss, mental clarity, improved sleep and better energy. But what if I told you fasting may also reset your immune system? Surprisingly, this “extra” benefit fits right into what we’re trying to accomplish with The Fast Patch—and it may be one of the most important pieces yet.
This matters to me because while I inherited a lot of great stuff from my mother, I also inherited her banged up immune system. She had Rheumatic Fever as a kid. I've been told by my grandma that she was always sick. I'm sick all the time, despite the fact that I am very conscientious of my health. So when this study was forwarded to me this morning by an old patient of mine, I was very happy to see it. It fits in perfectly with my fasting schedule.
“Prolonged fasting not only forces the body to use stores of glucose and fat, but also breaks down a significant portion of white blood cells. This triggers stem cell-based regeneration of new immune system cells.” ~Dr. Valter Longo, USC Leonard Davis School of Gerontology
The Study Breakdown: Immune System Reboot via Fasting
Researchers at the University of Southern California led by Longo found that when humans and animals fast for roughly 72 hours, something extraordinary happens. The body burns through its stores of glucose and fat, triggering a detox process where damaged white blood cells are cleared out.
What comes next? Stem cells in the hematopoietic system get switched on, regenerating a fresh wave of immune cells. That’s your immune system being rebuilt from the inside.
They even found key genes like PKA (protein kinase A) and IGF-1 (insulin-like growth factor) become suppressed during the fast, which triggers stem cell activation and renewal.
In plain terms: you fast → your body uses its internal fat & glucose reserves → damaged or old immune cells get cleared out → new, more efficient immune cells are formed.
Why This Matters to You (And How It Links To What We’re Doing)
At InsideOut Wellness, when I published my book, HCG 2.0 - Don't Starve, Eat Smart and Lose: A Modern Adaptation of the Traditional HCG Diet, and later developed The Fast Patch, it was always about one key principle: target stored fat, simplify the process, and let your body do the rest.
Fasting triggers ketosis (your body burning fat for fuel instead of glucose). It triggers autophagy (your internal cleanup crew). And now we see it can also trigger immune regeneration.
Here’s how it all ties together for you:
Stored fat = fuel reserve. Your body historically stored fat for a reason—today, that reserve often just sits there. Fasting and The Fast Patch help you tap it.
Ketosis gives you cleaner energy. When glucose is gone, your body burns fat (ketones) instead—less insulin, less inflammation, better clarity.
Autophagy sweeps up damaged cells. It’s “self-eating” in the best possible way—clearing out the old so the new can thrive.
Immune reboot is the next frontier. The USC study shows you can trigger a reset in your immune system, clearing old white blood cells and creating fresh ones. That’s resilience—not just weight loss.

“Fasting gives the ‘okay’ for stem cells to go ahead and begin proliferating and rebuild the entire system.” ~Dr. Valter Longo
Autophagy, Immunity, and Why Ketosis Matters
When you fast, your body shifts from processing constant food intake to an internal state of repair. Autophagy kicks in—cells clean house. Simultaneously, because you’re no longer feeding glucose constantly, your body shifts into fat-burning (ketosis).
That shift matters: glucose is short-term fuel; ketones are long-term, cleaner fuel. And while your body prefers glucose (because it’s easy), it stores fat for the “just in case” scenarios.
Fasting forces that scenario.
So while you’re in fat-burning and autophagy mode, you’re also in immune-regeneration mode (as the USC study indicates). It’s like turning your body into a repair factory: burning the old, building the new, refreshing your system from the inside out.
Strategic Value with The Fast Patch
You know I lost 11 pounds in 3 days with The Fast Patch before my big trip—and yes, part of that was the psychological win of looking and feeling sharp. But beyond the pounds, it reinforced this bigger message: when you fast strategically you get so much more than weight loss.
Use The Fast Patch for:
A pre-event fast (trim down, sharpen up)
A post-event detox (reset, clean up)
A regular 24-hour weekly fast + 3-day monthly fast schedule
Because when you add the immune and cellular benefits to the mix, it becomes a lifestyle—not a quick fix.
“When you starve, the system tries to save energy, and one of the things it can do to save energy is to recycle a lot of the immune cells that are not needed, especially those that may be damaged.” ~ Dr. Valter Longo, USC Leonard Davis School of Gerontology
The Big Takeaway
Fasting always did more than we initially thought. We understood fat loss and autophagy—now we’re understanding immune regeneration.
With The Fast Patch and the research behind it, you’re not just hitting a reset button—you’re pressing a whole system reboot.
You’re mobilizing fat for fuel. You’re cleaning out damaged cells. You’re renewing your immune system.
It’s about living at your best, not just being on a diet.
If you’re ready to step into that deeper experience—visit www.TheFastPatch.com and let’s make it happen.




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